2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136428R
    Desoxycarbadox (Standard)
    Desoxycarbadox (Standard) is the analytical standard of Desoxycarbadox. This product is intended for research and analytical applications. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.
    Desoxycarbadox (Standard)
  • HY-W019726R
    Dehydro Nifedipine (Standard)
    Dehydro Nifedipine (Standard) is the analytical standard of Dehydro Nifedipine. This product is intended for research and analytical applications. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies.
    Dehydro Nifedipine (Standard)
  • HY-N3995R
    5β-Dihydrocortisol (Standard)
    D-Psicose (Standard) is the analytical standard of D-Psicose. This product is intended for research and analytical applications. D-Psicose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    5β-Dihydrocortisol (Standard)
  • HY-W015590R
    2-Hydroxyphenylacetic acid (Standard)
    2-Hydroxyphenylacetic acid (Standard) is an analytical standard for 2-Hydroxyphenylacetic acid (HY-W015590). This product is intended for research and analytical applications. 2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, and is also a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid can be used as a potential biomarker for food. 2-Hydroxyphenylacetic acid can be used in the study of phenylketonuria and related hyperphenylalaninemias.
    2-Hydroxyphenylacetic acid (Standard)
  • HY-135404R
    Anhydrosimvastatin (Standard)
    Anhydrosimvastatin (Standard) is the analytical standard of Anhydrosimvastatin. This product is intended for research and analytical applications. Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase.
    Anhydrosimvastatin (Standard)
  • HY-119696S
    MTIC-d3
    MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the agent’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane.
    MTIC-d<sub>3</sub>
  • HY-N3059R
    Pinostilbene (Standard)
    Pinostilbene (Standard) is the analytical standard of Pinostilbene. This product is intended for research and analytical applications. Pinostilbene (trans-Pinostilbene) is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells.
    Pinostilbene (Standard)
  • HY-112226R
    VRT-043198 (Standard)
    VRT-043198 (Standard) is the analytical standard of VRT-043198. This product is intended for research and analytical applications. VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively[1].
    VRT-043198 (Standard)
  • HY-18719S
    Endoxifen-d5 (Z-isomer)
    Endoxifen-d5 (Z-isomer) is the deuterium labeled Endoxifen (Z-isomer) (HY-18719). Endoxifen (Z-isomer) is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen (Z-isomer) inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM.
    Endoxifen-d<sub>5</sub> (Z-isomer)
  • HY-135111R
    4-Desmethoxy Omeprazole (Standard)
    4-Desmethoxy Omeprazole (Standard) is the analytical standard of 4-Desmethoxy Omeprazole. This product is intended for research and analytical applications. 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
    4-Desmethoxy Omeprazole (Standard)
  • HY-Z0075R
    (Z)2S,4R-Sacubitril (Standard)
    (Z)2S,4R-Sacubitril (Standard) is the analytical standard of (Z)2S,4R-Sacubitril. This product is intended for research and analytical applications. (Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    (Z)2S,4R-Sacubitril (Standard)
  • HY-107447R
    N-Deshydroxyethyl Dasatinib (Standard)
    N-Deshydroxyethyl Dasatinib (Standard) is the analytical standard of N-Deshydroxyethyl Dasatinib. This product is intended for research and analytical applications. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research[1][2].
    N-Deshydroxyethyl Dasatinib (Standard)
  • HY-N7513R
    Homovanillyl alcohol (Standard)
    Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases.
    Homovanillyl alcohol (Standard)
  • HY-66008R
    N-Acetyl mesalazine (Standard)
    N-Acetyl mesalazine (Standard) (N-Acetyl-5-aminosalicylic acid (Standard)) is the analytical standard of N-Acetyl mesalazine (HY-66008). This product is intended for research and analytical applications. N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer.
    N-Acetyl mesalazine (Standard)
  • HY-135390
    Hydroxy desmethyl Bosentan
    Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension.
    Hydroxy desmethyl Bosentan
  • HY-12772S1
    (2R,4S)-Hydroxy Itraconazole-d8
    (2R,4S)-Hydroxy Itraconazole-d8 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].
    (2R,4S)-Hydroxy Itraconazole-d<sub>8</sub>
  • HY-136436S
    Ternidazole-d6 hydrochloride
    Ternidazole-d6 hydrochloride is the deuterium labeled Ternidazole hydrochloride (HY-136436). Ternidazole hydrochloride is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole hydrochloride kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole hydrochloride helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole hydrochloride effectively alleviates chronic alcoholism. Ternidazole hydrochloride can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism.
    Ternidazole-d<sub>6</sub> hydrochloride
  • HY-133794S
    Dasatinib N-oxide-d8
    Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor.
    Dasatinib N-oxide-d<sub>8</sub>
  • HY-B1398S
    Ampyrone-d3
    Ampyrone-d3 is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy.
    Ampyrone-d<sub>3</sub>
  • HY-132617S
    Carboxy Gliclazide-d4
    		Modulator
    Carboxy Gliclazide-d4 is the deuterium labeled Carboxy Gliclazide.
    Carboxy Gliclazide-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity